However, it was Sassuolo who stunned the home crowd and raced to a two-goal lead inside 22 minutes, as Grégoire Defrel and Davide Frattesi both found the net with clinical close-range efforts.
Having suffered just one defeat in their last 17 SA home matches, the Rossoneri responded in impressive fashion, with Olivier Giroud directing a superb header into the top corner to immediately halve the deficit.
In keeping with a remarkable opening half-hour, the visitors quickly restored their two-goal advantage, as the influential Domenico Berardi connected with Hamed Traorè’s corner to guide a header beyond Ciprian Tătărușanu.
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The French forward assumed responsibility from the spot and confidently drilled home, as Milan conceded four goals in consecutive SA matches for the first time in their history.
Faced with a daunting three-goal deficit, the hosts desperately searched for a route back into the contest going into the final half-hour, but Ante Rebić saw a well-taken effort disallowed for marginal offside, adding to the Rossoneri’s frustration.
This prompted large sections of the home support to leave with 10 minutes left to play, and despite a stunning consolation from Divock Origi, Milan succumbed in embarrassing fashion to a sixth consecutive match without victory for the first time since April 2018.
