Having claimed victory in eight of their previous nine matches on home soil, Roma looked full of confidence during the early stages, with Georginio Wijnaldum and Tammy Abraham both going close inside the opening 10 minutes.
Despite the hosts’ dominant start, Sassuolo soon settled into the contest, and duly found the opener, as Armand Laurienté tapped home after Rui Patrício could only parry a curled effort from Andrea Pinamonti.
Faced with a two-goal deficit, Roma responded in impressive fashion, and soon pulled a goal back, as Nicola Zalewski netted his first senior strike, placing an effort over Andrea Consigli and into the far corner.
The Sassuolo winger dusted himself off and coolly slotted home the resulting spot-kick to restore the visitors’ two-goal lead going into the interval.
Roma emerged after the restart desperate to claw their way back into the match, and halved the deficit within five minutes, as substitute Paulo Dybala curled a sublime long-range strike into the top corner.
Similar to the first half, Sassuolo showed impressive resolve to regain control of proceedings after Dybala’s moment of brilliance, and came within inches of restoring their advantage, when Berardi thundered a superb effort against the bar.
This all but ended the hosts’ resistance, as Sassoulo – despite a last-gasp consolation from Wijnaldum – made their way through the closing stages, to secure three brilliant points and extend their unbeaten SA away run to five matches.