Twelve years on from the famous handball that eventually sent Ghana packing at the Quarter-Final stage, Luis Suárez was on hand yet again twice assisting Giorgian de Arrascaeta in a 2-0 win.
La Celeste started the game as the only side yet to score a single goal in the tournament, but deployed a hugely attacking lineup knowing only a win would take them through.
Much to Uruguay’s dismay, VAR aided German referee Daniel Siebert in pointing to the spot, giving Ghana captain André Ayew the chance to avenge the painful 2010 Quarter-Final defeat which he missed due to suspension.
The penalty sparked Uruguay into life, first when Darwin Núñez forced Mohammed Salisu to clear off the line after chipping Lawrence Ati-Zigi in goal.
Ati-Zigi was disappointingly unable to hold, giving Giorgian de Arrascaeta a headed tap-in on his first start.
The same combination allowed La Celeste breathing space, with Suárez intricately flicking over the head of Alidu Seidu, before de Arrascaeta finished well on the volley.
In the end, Uruguay did their job, but were hugely disappointed as Portugal conceded late to a Hwang Hee-chan winner, sending South Korea through at expense of La Celeste on goals scored.