The Gunners moved eight points clear at the Premier League (PL) summit, with a result that also saw them complete the double over their arch rivals for the first time since 2014.
Mikel Arteta was the captain of the last Arsenal team to win on Spurs soil, and he masterminded a perfect first-half display where his men completely outclassed the hosts.
Seeds of doubt were planted early when Tottenham were caught out in possession in their own third, forcing Hugo Lloris to deny Eddie Nketiah.
Antonio Conte simply had no answer for the pressure his team was facing, and Martin Ødegaard’s effort from range brought a save from Lloris, before a rocket on the volley from Thomas Partey cannoned off the woodwork.
Having found his range, Arsenal’s Norwegian captain hit the target before the break to double their advantage, as he drilled into the bottom corner from outside the area, and left Spurs needing another rousing second-half performance.
Ramsdale continued his heroics moments later, as he denied Ryan Sessegnon from the inside left after the wing-back was slipped in by Kane.
After a frantic opening to the second period, Arsenal regained control and ought to have put the game to bed when Granit Xhaka slotted in Nketiah, but Lloris stood firm to deny him.